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Abd efficacy has been demonstrated in patients with mild vough moderate renal please click for source and gout. However, it can cause abnormalities in liver function tests and routine monitoring of bloodwork is recommended. Similar to allopurinol, there are interactions of febuxostat with azathioprine, 6MP, and theophylline. Uricase is an enzyme that converts poorly soluable urate uric acid to the more soluable allantoin excreted in the urine.

Uricase is present in most mammals, and these mammals with uricase do not develop gout. Bead, humans and some primates lack uricase because of evoluationary gene inactivation and lack the ability to make uric acid more soluable and hence, have gout.

Pegloticase is a porcine uricase which was approved by the FDA in September for best medicine for a head cold and cough treatment of gout in patients who have failed conventional therapy.

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